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Methyl 4-chloro-3-formylbenzoate, also known as CAS No:163702-08-7, is a colorless to pale yellow liquid with a faint, aromatic odor and a molecular formula of C10H7ClO3. It is a member of the class of compounds known as benzoates and is an aromatic ester. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other chemicals.
Methyl 4-chloro-3-formylbenzoate is soluble in water, alcohol, and other organic solvents, and is slightly soluble in ether. It has a melting point of -10°C and a boiling point of 261°C. It is a strong acid, with a pKa of 4.9. The structure of this compound is that of an aromatic ester, with a benzene ring attached to a carbonyl group.
Methyl 4-chloro-3-formylbenzoate can be synthesized by the reaction of 4-chlorobenzoic acid with formaldehyde in the presence of an acid catalyst. The reaction proceeds at a temperature of 80-90°C, with a yield of approximately 90%. The product can then be purified by recrystallization from an appropriate solvent.
Methyl 4-chloro-3-formylbenzoate has a variety of uses in the synthesis of pharmaceuticals and other chemicals. It is commonly used as an intermediate in the synthesis of quinolones, fluoroquinolones, and other drugs. It can also be used in the synthesis of perfumes, dyes, and other aromatic compounds.
Methyl 4-chloro-3-formylbenzoate is a toxic substance that should be handled with extreme care. It is irritating to the eyes, skin, and respiratory system, and should be stored in a cool, dry place away from light and heat. It should be handled with gloves and protective clothing, and should not be ingested, inhaled, or allowed to come in contact with the skin.